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| U-645 | Type VIIC |
| Feldpost Number | M 49 700 |
| Construction Yard | Blohm und Voß, Hamburg |
| Yard Number | 621 |
| Ordered | 20th Jan 1941 |
| Keel laid | 17th Dec 1941 |
| Launched | 3rd Sep 1942 |
| Commissioned | 22nd Oct 1942 |
| Baubelehrung | 8.KLA, Hamburg | | Training, Flotillas and Duties | | 10.42 - 04.43 | 5.U-Flottille, Kiel Ausbildungsboot (under training)
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| 05.43 - 12.43 | 3.U-Flottille, La Pallice Frontboot (operational)
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| Commanders | | 10.42 - 12.43 | LT Otto Ferro |
| Operations information for U-645 | 24.04.1943 - 22.06.1943 First Sailing - active patrol
U-645 left Kiel under the command of Otto Ferro on 24th Apr 1943 and arrived at Brest on 22nd Jun 1943 after eight and a half weeks. At 1500 HRS on 6th May 1943 in square AL 23, U-645 came under attack from an unidentified aircraft. At 1603 HRS on 19th May 1943 in square AK 54, U-645 came under attack from an aircraft of RAF 120 Squadron. At 0306 HRS on 21st May 1943 in square AK 64, U-645 came under attack from an unidentified aircraft. At 1300 HRS on 12th Jun 1943 in square BD 36, U-645 came under attack from an aircraft of RAF 86 Squadron. U-645 was only slightly damaged in the attack. The boat defended itself with flak without destroying the aircraft. At 1623 HRS on 12th Jun 1943 in square BE 14, U-645 came under attack from an aircraft of RAF 86 Squadron. The boat defended itself with flak without destroying the aircraft. On 18th Jun 1943 in square BE 92, U-645 came under attack from an aircraft of RAF 59 Squadron. The boat defended itself with flak without destroying the aircraft. On 19th Jun 1943 in square BE 93, U-645 came under attack from an aircraft of RAF 236+248 Squadron.
| 23.08.1943 - 21.10.1943 Second Sailing - active patrol
On the 23rd Aug 1943, U-645 left Brest under the command of Otto Ferro and after eight and a half weeks arrived at La Pallice on 21st Oct 1943.
Otto Ferro hit two ships on this patrol and both of them were in convoy: One was from convoy ON-202 and one was from convoy SC-143.
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On 20th Sep 1943 he sank the American 7,176 ton Frederick Douglass, sailing with convoy ON-202.
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On 9th Oct 1943 he sank the American 5,612 ton Yorkmar, a member of convoy SC-143.
| 02.12.1943 - 24.12.1943 Third Sailing - active patrol
U-645 departed under Otto Ferro from La Pallice on 2nd Dec 1943. The boat was sunk on 24th Dec 1943.
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